Cationic Porphyrin Induced a Telomeric DNA to G-Quadruplex Form in Water
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Cationic Porphyrin Induced a Telomeric DNA to G-Quadruplex Form in Water
The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.
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A water soluble Zn(II) porphyrazine drives the conformational equilibrium of the G-quadruplex of a human telomeric sequence exclusively towards a parallel conformation upon complexation.
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The design and synthesis of metal complexes that can specifically target DNA secondary structure has attracted considerable attention. Chiral metallosupramolecular complexes (e.g. helicates) in particular display unique DNA-binding behavior, however until recently few examples which are both water-compatible and enantiomerically pure have been reported. Herein we report that one metallohelix en...
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ژورنال
عنوان ژورنال: Bioinorganic Chemistry and Applications
سال: 2008
ISSN: 1565-3633,1687-479X
DOI: 10.1155/2008/294756